L-Arginine is a conditionally essential amino acid found in the diet. It’s a health supplement used mostly by individuals because it is the amino acid that directly generates nitric oxide through the nitric oxide synthase enzymes.

It’s especially valuable during periods of illness and chronic conditions like high blood pressure and type II diabetes mellitus, as these countries have a propensity to be characterized by a growth in the enzyme that diminishes L-arginine (known as arginase) leading to a transient deficiency; this precedes a rise in blood pressure level in these states, and may be partially remedied by a rise in L-arginine intake or resolution of the illness/disease state.

L-arginine is a popular nutritional supplement for athletes as it is touted to increase nitric oxide activity within the body. Sadly, this impact appears to be unreliable in otherwise healthy adults. While there have been studies that have measured increased effects of nitric oxide (flow of blood) they’re paired with studies showing no apparent consequences. As for the mechanism, there’s reason to believe that this distinction is in part due to inadequate absorption of L-arginine from the intestines before it may reach activity within the human body.

L-Citrulline is different supplementation option because it is converted into arginine in the kidneys. Additionally, it has a better absorption rate. Citrulline is in a position to increase amounts of plasma arginine more efficient compared to arginine itself. For long-term health-related supplementation, L-citrulline can be a better supplementation option compared to L-arginine.

Recommended dosage, active amounts, other Particulars

The conventional pre-workout dose for L-arginine is 3-6g.

To maintain high arginine levels through the day, arginine may be taken up to 3 times a day, with a joint dose total of 15-18g. Notice: L-Citrulline supplementation is significantly more efficient at maintaining arginine amounts that are elevated for extended time periods.

Taking excess than 10g of arginine at once can result in gastrointestinal discomfort and nausea.


Chest pain (angina)

Taking L-arginine seems to minimize symptoms and improve exercise tolerance and quality of life in individuals with angina. Nevertheless, L-arginine doesn’t seem to develop the disease itself.

Erection dysfunction (ED)

Taking 5 grams of L-arginine by mouth daily seems to improve sexual function in guys with ED. Taking doses may not be effective. Nevertheless, some signs adding 40 mg of Pycnogenol 3 times each day may improve the efficacy of low-dose L-arginine for ED.

High blood pressure amount

There’s early evidence that taking can reduce blood pressure amount in healthy people, individuals with higher blood pressure level, and people with slightly higher blood pressure degree without or with diabetes mellitus.

Inflammation of the digestion tract

Adding L-arginine to formula seems to counter inflammation of the digestion tract.

Nitrate tolerance

Taking 700 milligrams of L-arginine 4 times per day seems to prevent nitrate tolerance in individuals taking nitroglycerin for chest pain (angina pectoris).

Leg pain associated with inadequate blood circulation

Studies suggest that taking L arginine by mouth or intravenously for up to 8 months increases blood circulation in people with the peripheral arterial disease. But, long-term use doesn’t improve walking pace or space in people with the peripheral arterial disease.

Improving recovery

Taking L arginine with ribonucleic acid and eicosapentaenoic acid before surgery or later seems to help lessen the recovery time, reduce the number of infections and promote the wound healing. 

High blood pressure level while pregnant

Even though there are inconsistent results about the effect of L arginine on pre-eclampsia, most studies suggest that it may reduce blood pressure level in women with this condition.

Bipolar disease

Early studies suggest that taking L-arginine, either by mouth for up to six months or weeks for a brief time, doesn’t improve kidney function in people with kidney failure or kidney disease. But, taking 1.3 grams of L-arginine by mouth every day appears to improve kidney function and inverse anemia in older people with a renal failure associated nausea.

Heart attack

Taking L doesn’t seem to assist in preventing a heart attack. It doesn’t seem to be beneficial for treating a myocardial infarction once it’s occurred. In reality, there’s concern that L arginine could be harmful to individuals following a heart attack. Don’t take L-arginine when you’ve had a heart attack. 

Wound healing

Taking L doesn’t appear to improve wound healing. 

AIDS-related to wasting

Taking L arginine by mouth, together with hydroxymethyl butyrate and glutamine, for two months seems to increase body fat and improve immune function in people with HIV/AIDS. Nevertheless, taking 7.4 grams of L arginine by mouth every day, together with omega-3 fatty acids along with balanced food supplement for two months doesn’t improve body fat or fat mass, energy consumption, or immune function in individuals who’re HIV positive. 

Altitude sickness

Early studies suggest that L arginine doesn’t reduce altitude sickness.

Anal fissures

There’s inconsistent evidence about that effects of L arginine for healing anal fissures. Implementing L arginine on the skin twice per day for three months is less efficient than surgery for healing anal fissures. Employing a topical gel containing L arginine five times per day for at least 12 weeks could cure cracks in individuals who don’t respond to traditional maintenance.

Breast cancer

Historical research demonstrates that taking L arginine before chemotherapy doesn’t improve the response rate in people with breast cancer.

Congestive heart failure

Taking L arginine by mouth, together with conventional therapy, appears to improve kidney function in people with heart failure. But, it could not develop the capability to exercise, quality of life, or blood circulation. L arginine shouldn’t be utilized in place of conventional treatment.

Clogged blood vessels

Early studies suggest that taking L arginine intravenously before exercising may enhance blood vessel function in individuals with coronary artery disease. It doesn’t improve blood circulation to the heart. Critical illness. Research demonstrates that taking L arginine by mouth with glutamine, nucleotides, and omega-3 fatty acids reduce the recovery time, requirement for ventilation and the risk of infection in individuals who’re ill. It does not lessen the possibility of death.

Memory loss

Early studies suggest that L arginine could improve loss of memory related to aging. Cavities. Initial research suggests that having Dairy-free mint containing arginine complicated for one year reduces the number of cavities within molars of children in comparison with sugarless mints that don’t include arginine.

Sensitive teeth

Early studies suggest that utilizing a toothpaste containing calcium, arginine, and fluoride reduces the sensitivity of the tooth when used daily.


Taking L arginine by mouth for 30 days appears to improve blood sugar control in people with diabetes. L arginine seems to enhance the sensitivity of insulin and blood pressure level in individuals with type two diabetes.

Diabetic foot ulcers

Historical research demonstrates that employing L arginine to the legs daily may improve circulation in individuals with diabetes mellitus, which could be beneficial in preventing diabetic foot ulcer. But when there’s already an ulcer on foot, then injecting L-arginine under the skin near the uterus doesn’t look to shorten healing time or lower the possibility of having an amputation in the future.

Nerve harm due to diabetes

Early studies suggest the taking L-arginine daily for three months does not improve neural damage related to diabetes.

Muscle problems in the esophagus

Early research suggests that getting an L-arginine infusion and taking L-arginine lessens the number and intensity of chest pain attacks in individuals with muscular esophagus problems and chest pain that’s not linked to the heart disease

Exercise functionality

There’s inconsistent evidence about the effect of L-arginine on exercise performance. Some evidence shows that taking 6 grams of L-arginine at a beverage increases exercise time. Nevertheless, other evidence indicates that taking L-arginine, alone or together with antioxidants, doesn’t improve performance in cyclists. 

Neck and head cancer

Supplementing a feeding tube with L-arginine doesn’t appear to enhance immune function, decrease tumor size, or enhance healing in individuals with neck and head cancer. 

Coronary artery bypass graft operation

There’s mixed evidence on the effect of L-arginine in protecting the heart during CABG. Early studies suggest that administering L-arginine intravenously will help keep the pressure in the blood vessels and flow of blood in individuals undergoing CABG. It doesn’t reduce complications after an operation or the quantity of time spent at the hospital. 

Heart transplant

Early studies suggest that taking L arginine increases walking distance and also enhances breathing in people with heart transplants.


There is inconsistent evidence about the efficacy of L arginine for infertility. Some research indicates that taking 16 grams of L arginine increases egg counts collected in women undergoing IVF. It doesn’t appear to enhance pregnancy rates. Other research suggests that taking L arginine doesn’t improve semen quality in guys with unexplained infertility.

Bladder inflammation

Taking L-arginine by mouth appears to reduce pain and a few signs of urinary bladder inflammation, although improvements might take three months to happen. L-arginine doesn’t seem to reduce the need to urinate during the night time or enhance the frequency of urination.

Poor development of fetus

Early research indicates that taking L-arginine may increase the birthweight of infants who show poor progress while in their mother’s womb. Nevertheless, L-arginine doesn’t appear to improve birthweight or reduce the probability of the infant dying if the infant has feeble growth while in the uterus.

Mitochondrial encephalomyopathies

There’s some interest in using L-arginine to improve the symptoms associated with MELAS syndrome. Early research indicates that administering L-arginine within one hour of stroke-like symptoms enhances a headache, nausea, vomiting, blindness, and also the appearance of bright areas in individuals with this condition.

Migraine headache

Taking L arginine orally with the painkiller aspirin appears to be advantageous for treating migraine headache. This combination sometimes begins to work in 30 minutes. It is difficult to know how much of the pain relief is because of L arginine, because aspirin may relieve migraine pain on its own.

Ovarian disease

Early research indicates that taking N acetyl cysteine and L daily for six months may enhance menstrual function and reduces insulin resistance in individuals with polycystic ovarian syndrome.

Pressure ulcers

Taking L-arginine orally with the painkiller aspirin appears to be advantageous for treating migraine headache.This combination sometimes begins to work in 30 minutes. It is difficult to know how much of the pain relief is because of L-arginine, because aspirin may relieve migraine pain on its own. Restricted blood circulation. Some evidence indicates that administering L-arginine through implantation followed by supplementation by mouth for two weeks after stent implantation doesn’t reduce the potential risk of limited blood circulation. Nevertheless, other evidence indicates which administering L-arginine in the website of implantation might minimize artery wall thickening. 

Kidney transplant

There are conflicting signs on the effects of L arginine for individuals with kidney transplants. Early research indicates that taking L-arginine improves kidney function. Nevertheless, other evidence suggests that L arginine doesn’t improve kidney function. The inconsistencies can be because of other factors associated with the transplant process. 

Respiratory infections

Early research indicates that taking L arginine by mouth for sixty days prevents the recurrence of respiratory infections in children.

Sickle-cell disease


Prevention of the common cold

Female sexual problems

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