L-Citrulline is among the 3 dietary amino acids at the urea cycle, alongside L-arginine and L-Ornithine.

It is utilized as a sports performance and cardiovascular health supplement. Supplementation results in reduced fatigue and improved endurance for both anaerobic and aerobic prolonged exercise. There’s insufficient evidence to support the claim that supplementation improves power output during exercise.

Supplementing increases ornithine and arginine plasma content. This implies supplementation improves the ammonia recycling process and oxide process. L-citrulline is utilized to alleviate erection dysfunction brought on by elevated blood pressure amount.

After supplementation, L-citrulline is converted into arginine from the uterus. Supplemental L-arginine supplies a spike of L-arginine in plasma, while supplemental increases arginine plasma levels over a longer duration of time.

L-arginine and L-ornithine are susceptible to reduced absorption when supplemented in doses of 10g or more, which can lead to diarrhea. It doesn’t have this side-effect, also because it increases plasma levels of all three amino acids, it’s usually preferred as a supplement over L-arginine. Though it doubles ornithine plasma content, L-ornithine supplementation may increase ornithine plasma content even more.

Recommended dosage, active amounts, other details

To supplement L-citrulline for circulatory health or to alleviate erection dysfunction, take 1,000 mg of citrulline, 3 times a day with meals, for a total daily dose of 3,000 mg. It  doesn’t have to be taken with meals, however.

To supplement for circulatory health with a citrulline malate supplement, take 1.76 g of citrulline malate for every 1 gram of citrulline you’d ordinarily take.

To supplement it to enhance sports performance, take 6,000 — 8,000 mg of citrulline malate about an hour before workout.


Exercise performance

L-citrulline may not be effective for improving exercise performance. In one research test, L-citrulline did not improve performance on a treadmill system. Individuals who took it really became tired faster than those who did not take it.

High blood pressure amount in kids after heart surgery

It might help decrease the elevated blood pressure amount which might happen after heart surgery in kids. It’s given later and before the surgery.

Sickle cell disease

 L-citrulline may improve some symptoms in people with sickle cell disease.

Other conditions.  


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